Aspirin
Aspirin's possible cancer-protective effects may be due to the prevention of inflammation which could provide a boost to the growth of cancer cells. Some studies suggest that aspirin targets cancer stem cells which is at the root to cancer growth and metastasis. Though the science is relatively new, researches suspect that aspirin is most effective against the type of cancer responsible for breast, prostate, esophageal and colorectal tumors.
Aspirin has also been tested in the lab to show that it has an effect on the onset of replicative senescence. Semescence is the stage before cell death (apoptosis) where cells can no longer replicate themselves by division. This tells us that aspirin can delay the onset of senescence by decreasing reactive oxygen species (ROS) and increasing nitric oxide (NO) along with cGMP levels. Shortening of telomeres and decrease of telomerase is another mechanism that induces senescence. Aspirin increased telomerase activity significantly.
It is also proported that chronic use of Aspirin as a non-steroidal anti-inflammatory drug can inhibit amyloid-betta aggregation which can prevent and treat Alzheimer's disease, arthritis, cardiovascular disease and cancer (age related diseases).
Buffered aspirin has relatively good bio-availability as compared to other forms.
Sources:
Aspirin has also been tested in the lab to show that it has an effect on the onset of replicative senescence. Semescence is the stage before cell death (apoptosis) where cells can no longer replicate themselves by division. This tells us that aspirin can delay the onset of senescence by decreasing reactive oxygen species (ROS) and increasing nitric oxide (NO) along with cGMP levels. Shortening of telomeres and decrease of telomerase is another mechanism that induces senescence. Aspirin increased telomerase activity significantly.
It is also proported that chronic use of Aspirin as a non-steroidal anti-inflammatory drug can inhibit amyloid-betta aggregation which can prevent and treat Alzheimer's disease, arthritis, cardiovascular disease and cancer (age related diseases).
Buffered aspirin has relatively good bio-availability as compared to other forms.
Sources:
New
Evidence That Aspirin May Prevent Cancer - Forbes
Aspirin reduces endothelial cell ... [Biochem Biophys Res Commun. 2005] - PubMed - NCBI
Aspirin and non-steroidal anti-inflammatory drug... [Neuroreport. 2001] - PubMed - NCBI
Aspirin: effects, poisoning | The Children's Hospital of Philadelphia
Aspirin Reduces Endothelial Cell Senescence
Comparative bioavailability of aspirin from buffered, enteric-coated and plain preparations.
Asprin as an inhibitor of glycation
Asprin as an AGEs inhibitor
Aspirin reduces endothelial cell ... [Biochem Biophys Res Commun. 2005] - PubMed - NCBI
Aspirin and non-steroidal anti-inflammatory drug... [Neuroreport. 2001] - PubMed - NCBI
Aspirin: effects, poisoning | The Children's Hospital of Philadelphia
Aspirin Reduces Endothelial Cell Senescence
Comparative bioavailability of aspirin from buffered, enteric-coated and plain preparations.
Asprin as an inhibitor of glycation
Asprin as an AGEs inhibitor