RepliniSENS - Replacing lost cells
RepleniSENS is any attempt to repair cell loss by targeting specific cells with a programmed stem cells to regrow cells lost through apoptosis (cell death) or death by trauma. This is accomplished by bypassing the embryonic stem cell state with a cell that acts like them called induced pluripotent stem cells. Pluripotent stem cells (Also known as embryonic stem cells) can develop into any cell type in the body. Adult Pluripotent stem cells are very rare and few in numbers. RepleniSENS best promise is the generation of totally new organs made from the body of the recipient. This science is very theoretical, experimental and no actual therapies are available to the public.
What if anything can we do if this new technology is not available to us to replenish our cells? The answer is already in me and these are called adult stem cells. We all have them and they come in different types. Each type differentiates to replace particular human cells when they die. In other words they accomplish the same goal as RepleniSENS, yet naturally. It has been determined that by the age of 35 we will lose 45% of our adult stem cells, 50% by age 50 and 90% by age 65. The question is are they limited in number?
Genetics plays allot to how many stem cells a person is born with. This explains why some people naturally live longer than others. Their bodies can replace dead cells more quickly. Stem cells are undifferentiated cells. This means that they have no specialization. These cells go through two different stages. The first stage is one of self-renewal whereby through cycles of cell division stem cells self replicate. The second stage is that of differentiation where the stem cells divide and instead of becoming two stem cells create a sister stem cell and a progenitor cell. Progenitor cells then go through division and become normal specialized cells. What is puzzling is that stem cells are potentially immortal. Why then are they lost?
As stem cells go through division they collect a small fragment of intracellular molecules. These molecules can create havoc on stem cells and cause Oxidative Stress if not regulated properly. This can result in ROS (reactive oxygen species) and in turn result in senescence (non-dividing cells) or apoptosis (cell death) if it is not regulated. Another result of these rogue molecules can effect glycosis in the stem cells. Stem cells heavily rely on glycosis (sugar formation) to drive their metabolic activities. SIRT1 (SIRTUIN1) is an enzyme which plays a major role in the process of glycosis and these very same rogue molecules can hamper glycosis by breaking the SIRT1 mechanism. This can be detrimental to the survival of my stem cells. There is also the natural wear on stem cells as they divide which can result in the loss of telomeres. Stem cells therefore can die from natural age.
So, I can see why it is important to salvage as many stem cells as possible. From what I know I can do this through supplementation that 1) Prevents Senescence, 2) Prevents Apoptosis and 3) Encourages stem cell growth. What supplements could help me with this?
Astragalus
Astragalus stimulates the body's release of Telomerase which is a necessary component of TERT. TERT is necessary for telomere growth and stem cell activation. This will deal with the problem of the natural aging of stem cells.
c60-EVoo
c60 and olive oil is a super antioxidant which has the ability to pass through cell barriers. Once inside a stem-cell it can help neutralize rogue molecules and perhaps transport them out of the cell. This will help prevent unregulated ROS and oxidative stress. In turn I have dealt with senescence, apoptosis and have encouraged growth.
Carnosine and Blueberry Extract
Carnosine has been demonstrated to extend cellular life through it's ability to rejuvenate cells approaching senescence. Blueberry Extract has been shown to increase neurogenesis. Combined they have been shown to increase stem cell proliferation by 83%. This encourages stem cell growth.
Resveratrol
It has been demonstrated that resveratrol stimulates an abundance of SIRT-1 and subsequently helps prevent the breakdown of the process of glycosis within the stem cell. This prevents Senescence, apoptosis, and encourages stem cell growth.
What if anything can we do if this new technology is not available to us to replenish our cells? The answer is already in me and these are called adult stem cells. We all have them and they come in different types. Each type differentiates to replace particular human cells when they die. In other words they accomplish the same goal as RepleniSENS, yet naturally. It has been determined that by the age of 35 we will lose 45% of our adult stem cells, 50% by age 50 and 90% by age 65. The question is are they limited in number?
Genetics plays allot to how many stem cells a person is born with. This explains why some people naturally live longer than others. Their bodies can replace dead cells more quickly. Stem cells are undifferentiated cells. This means that they have no specialization. These cells go through two different stages. The first stage is one of self-renewal whereby through cycles of cell division stem cells self replicate. The second stage is that of differentiation where the stem cells divide and instead of becoming two stem cells create a sister stem cell and a progenitor cell. Progenitor cells then go through division and become normal specialized cells. What is puzzling is that stem cells are potentially immortal. Why then are they lost?
As stem cells go through division they collect a small fragment of intracellular molecules. These molecules can create havoc on stem cells and cause Oxidative Stress if not regulated properly. This can result in ROS (reactive oxygen species) and in turn result in senescence (non-dividing cells) or apoptosis (cell death) if it is not regulated. Another result of these rogue molecules can effect glycosis in the stem cells. Stem cells heavily rely on glycosis (sugar formation) to drive their metabolic activities. SIRT1 (SIRTUIN1) is an enzyme which plays a major role in the process of glycosis and these very same rogue molecules can hamper glycosis by breaking the SIRT1 mechanism. This can be detrimental to the survival of my stem cells. There is also the natural wear on stem cells as they divide which can result in the loss of telomeres. Stem cells therefore can die from natural age.
So, I can see why it is important to salvage as many stem cells as possible. From what I know I can do this through supplementation that 1) Prevents Senescence, 2) Prevents Apoptosis and 3) Encourages stem cell growth. What supplements could help me with this?
Astragalus
Astragalus stimulates the body's release of Telomerase which is a necessary component of TERT. TERT is necessary for telomere growth and stem cell activation. This will deal with the problem of the natural aging of stem cells.
c60-EVoo
c60 and olive oil is a super antioxidant which has the ability to pass through cell barriers. Once inside a stem-cell it can help neutralize rogue molecules and perhaps transport them out of the cell. This will help prevent unregulated ROS and oxidative stress. In turn I have dealt with senescence, apoptosis and have encouraged growth.
Carnosine and Blueberry Extract
Carnosine has been demonstrated to extend cellular life through it's ability to rejuvenate cells approaching senescence. Blueberry Extract has been shown to increase neurogenesis. Combined they have been shown to increase stem cell proliferation by 83%. This encourages stem cell growth.
Resveratrol
It has been demonstrated that resveratrol stimulates an abundance of SIRT-1 and subsequently helps prevent the breakdown of the process of glycosis within the stem cell. This prevents Senescence, apoptosis, and encourages stem cell growth.