TA-711
ALT-711, trade name Alagebrium, is the only true advanced glycation end-products (AGEs) breaker. AGEs is notably one of the greatest known cause of aging. Primarily AGEs deals with the end products of our cells when they burn off sugars in our body. These byproducts are secreted out of the body's cells and binds with proteins to cause extracellular junk which builds up between cells. This is the cause of our degrading physical condition as we grow old. Our skin looses its elasticity, we begin to loose our sight, hearing and our arteries and heart begin to harden. Further damage is caused by a release of compounds triggered by AGE receptors called RAGEs. This inflammation causes the creation of hardened fibrous tissues which can further damage the circulatory system, heart and brain. There are other products which can slow or inhibit AGEs. For the exception of Aminoguanidine, we will discuss these AGE inhibitors later.
ALT-711 is specifically known to reverse AGEs in the heart and circulatory system. Overall it is known to reduce the body's AGEs and is later excreted through urine. High blood pressure patients treated with 210mg twice daily for eight weeks incurred an increase blood flow of nearly 80% and had their arterial stiffness reduced by 37%. Elderly patients with diastolic heart failure were also treated with ALT-711had the left ventricle of their hearts decrease in mass and subsequently their quality of life increased by 25%. ALT-711 not only breaks AGEs but it also significantly reduces RAGEs.
Another product called Aminoguanida is a known AGEs inhibitor. The company who designed ALT-711 when conducting trials say that Aminoguanida when used with ALT-711 further helps reduce proteins that result in kidney disease , delay renal disease and improve cholesterol profiles. Aminoguanida is able to reduce the damage of diabetes.
The company who owns the patent to ALT-711 has not been able to get their product approved by the FDA and their ability to do so is seriously in doubt. Consequently a grey market has sprung up and unlicensed ALT-711 products are available on the internet.
Sources:
ALT-711 is specifically known to reverse AGEs in the heart and circulatory system. Overall it is known to reduce the body's AGEs and is later excreted through urine. High blood pressure patients treated with 210mg twice daily for eight weeks incurred an increase blood flow of nearly 80% and had their arterial stiffness reduced by 37%. Elderly patients with diastolic heart failure were also treated with ALT-711had the left ventricle of their hearts decrease in mass and subsequently their quality of life increased by 25%. ALT-711 not only breaks AGEs but it also significantly reduces RAGEs.
Another product called Aminoguanida is a known AGEs inhibitor. The company who designed ALT-711 when conducting trials say that Aminoguanida when used with ALT-711 further helps reduce proteins that result in kidney disease , delay renal disease and improve cholesterol profiles. Aminoguanida is able to reduce the damage of diabetes.
The company who owns the patent to ALT-711 has not been able to get their product approved by the FDA and their ability to do so is seriously in doubt. Consequently a grey market has sprung up and unlicensed ALT-711 products are available on the internet.
Sources:
Alagebrium
chloride protects t... [J Gerontol A Biol Sci Med Sci. 2009] - PubMed
- NCBI
Anti-Aging Medicine: Current Therapies from the Science of Life-Extension
ALT-711: Safe and Effective Anti-AGE-ing Therapy : Vanuatu Medical, Ltd.
Crosslink breakers: a new approach to card... [Curr Opin Cardiol. 2004] - PubMed - NCBI
The End of ALT-711 / Alagebrium
11TOLSJ.pdf (application/pdf Object)
Anti-Aging Medicine: Current Therapies from the Science of Life-Extension
ALT-711: Safe and Effective Anti-AGE-ing Therapy : Vanuatu Medical, Ltd.
Crosslink breakers: a new approach to card... [Curr Opin Cardiol. 2004] - PubMed - NCBI
The End of ALT-711 / Alagebrium
11TOLSJ.pdf (application/pdf Object)