Methodology of Supplementation
"Aging is a three-stage process: metabolism, damage, and pathology. The biochemical processes that sustain life generate toxins as an intrinsic side effect. These toxins cause damage, of which a small proportion cannot be removed by any endogenous repair process and thus accumulates. This accumulating damage ultimately drives age-related degeneration. Interventions can be designed at all three stages. However, intervention in metabolism can only modestly postpone pathology, because production of toxins is so intrinsic a property of metabolic processes that greatly reducing that production would entail fundamental redesign of those processes. Similarly, intervention in pathology is a “losing battle” if the damage that drives it is accumulating unabated. By contrast, intervention to remove the accumulating damage would sever the link between metabolism and pathology, and so has the potential to postpone aging indefinitely. We survey the major categories of such damage and the ways in which, with current or foreseeable biotechnology, they could be reversed. Such ways exist in all cases, implying that indefinite postponement of aging—which we term 'engineered negligible senescence'—may be within sight. Given the major demographic consequences if it came about, this possibility merits urgent debate." - Time to talk SENS, Dr. Aubrey de Grey, Department of Genetics, University of Cambridge
The SENS Research Organization has identify seven targets that must be addressed if an aging regime is to reverse or halt the effects of old age:
RepleniSENS - Replacing lost cells
OncoSENS - Making cancerous mutations harmless
MitoSENS - Preventing damage from mitochondrial mutations
ApoptoSENS - Removing dysfunctional cells
GlycoSENS - Breaking extracellular cross-links
AmyloSENS - Removing junk from between cells
LysoSENS - Clearing wast accumulations out of cells
My goal will be to address these using whatever means is available to me today. My regime will focus on cellular repair and maintenance to encompass the benefits of knowledge gained from studying these seven targets. Time permitting I will justify my supplementation choices using them. In a best scenario I will be able to address all seven, yet I admit that the science is not completely there to reverse these problems. At best I can only stymie them to prevent age related disease and perhaps extend my life by a small factor.
The spreadsheet below is a summary of my research. This spreadsheet is a working document and will change as I narrow, refine and clarify these scores. Understand that I am not suggesting I take all of these supplements but only wish to reduce them to the ones that mostly address the SENS targets. I will post any changes to my regimen in the "My Regimen" page which you can see using the link in the left menu.
Edited 6 July, 2013
Supplement
|
Repleni SENS
|
Onco SENS
|
Mito SENS
|
Apopto SENS
|
Glyco SENS
|
Amylo SENS
|
Lyso SENS
|
Noot
|
Telomere Inhibitor
|
Telomere Protector
|
Telomere Activator |
|||||||
0
|
2
|
3B
|
0
|
3A
|
3A
|
3B
|
3C
|
0
|
0
|
0
|
||||||||
TA-711
^
|
0
|
0
|
0
|
0
|
3A
|
0
|
0
|
0
|
0
|
0
|
0
|
|||||||
0
|
1
|
0
|
2
|
3A
|
3B
|
3C
|
0
|
0
|
0
|
3A
|
||||||||
3B
|
3B
|
3
|
3
|
0
|
0
|
0
|
0
|
0
|
0
|
3A
|
||||||||
1
|
3A
|
3A
|
1
|
0
|
0
|
1
|
0
|
0
|
3A
|
0
|
||||||||
L-Carnosine
(2) ! #
|
3A
|
2
|
3
|
3
|
3A
|
0
|
0
|
0
|
0
|
3B
|
0
|
|||||||
Blueberry Extract (2)
|
3A
|
2
|
2
|
2
|
2
|
2
|
0
|
2
|
0
|
2
|
0
|
|||||||
Resveratrol (5)(6)
#
|
3B
|
3A
|
3A
|
3
|
0
|
0
|
0
|
1
|
3A
|
2
|
||||||||
Ginseng Extract
|
3C
|
3B
|
3
|
3
|
2
|
3B
|
0
|
2
|
0
|
3
|
0
|
|||||||
Curcumin (6) #
|
2
|
3A
|
0
|
0
|
0
|
3B
|
0
|
1
|
3
|
0
|
0
|
|||||||
Milk Thistle
|
0
|
3B
|
0
|
3
|
0
|
3B
|
0
|
0
|
3A
|
0
|
0
|
|||||||
(EGCG) (5)(6) #
|
3B
|
3A
|
3
|
3
|
3B
|
3B
|
0
|
2
|
3B
|
0
|
0
|
|||||||
Quercetin #
|
0
|
3B
|
3A
|
3
|
0
|
3C
|
3
|
2
|
3B
|
0
|
0
|
|||||||
Alpha Lipoic Acid (1)
#
|
2
|
3B
|
3
|
3
|
3A
|
0
|
3
|
3
|
0
|
3
|
0
|
|||||||
ALCAR (1) # |
0
|
0
|
3
|
3
|
0
|
3B
|
0
|
3
|
0
|
3
|
0
|
|||||||
Coenzyme Q10 (1)
#
|
3C
|
3B
|
3
|
0
|
3C
|
2
|
3
|
0
|
0
|
3
|
0
|
|||||||
Vitamine C #
|
3B
|
3B
|
3
|
3
|
3C
|
2
|
3
|
0
|
0
|
3
|
0
|
|||||||
Vitamine E
|
2
|
3B
|
2
|
0
|
1
|
3C
|
2
|
1
|
3C
|
2
|
0
|
|||||||
He Shou Wu
|
3C
|
3B
|
0
|
0
|
0
|
2
|
0
|
1
|
0
|
0
|
0
|
|||||||
Benfotiamine #
|
2
|
0
|
3
|
0
|
3B
|
3B
|
3
|
1
|
0
|
0
|
0
|
|||||||
Vitamin D/D3 (5)
#
|
2
|
3A
|
2
|
3B
|
0
|
3B
|
0
|
1
|
3C
|
0
|
0
|
|||||||
Caffeine (5)
|
0
|
2
|
3
|
0
|
0
|
3C
|
0
|
3
|
0
|
0
|
0
|
|||||||
Cinnamon
|
0
|
3B
|
0
|
0
|
2
|
3B
|
0
|
3
|
0
|
2
|
0
|
|||||||
Grape Seed Extract #
|
0
|
3B
|
0
|
0
|
3B
|
3B
|
3B
|
2
|
0
|
0
|
3B
|
|||||||
Creatine
|
3C
|
0
|
3A
|
0
|
0
|
0
|
0
|
2
|
0
|
0
|
0
|
|||||||
B-complex B6/B9/B12
|
2
|
1
|
3A
|
3B
|
2
|
0
|
2
|
2
|
0
|
0
|
2
|
|||||||
IP6
|
0
|
3A
|
3A
|
0
|
0
|
3B
|
3B
|
0
|
3A
|
0
|
0
|
|||||||
Centrophenoxine #
|
0
|
0
|
0
|
3B
|
0
|
3B
|
3B
|
3A
|
0
|
0
|
0
|
|||||||
Melatonin
|
3A
|
3A
|
3B
|
3A
|
0
|
3C
|
0
|
2
|
3
|
0
|
0
|
|||||||
NAC #
|
0
|
2
|
3C
|
2
|
3A
|
0
|
0
|
0
|
0
|
0
|
2
|
|||||||
L-Taurine !
|
3C
|
2
|
3A
|
0
|
3C
|
0
|
1
|
0
|
0
|
0
|
0
|
|||||||
L-Histidine !
|
0
|
0
|
3C
|
0
|
3C
|
0
|
0
|
2
|
0
|
0
|
0
|
|||||||
Fisetin (6)
|
0
|
3A
|
3
|
0
|
3
|
3A
|
0
|
3A
|
3A
|
0
|
0
|
|||||||
PQQ (6) #
|
0
|
3A
|
3A
|
0
|
0
|
3A
|
0
|
2A
|
0
|
0
|
0
|
|||||||
Fish Oil (6)
|
0
|
3A
|
3A
|
0
|
3B
|
0
|
3A
|
2B
|
3B
|
0
|
0
|
|||||||
SAMe (6)
|
2
|
3A
|
3B
|
0
|
0
|
3B
|
0
|
3B
|
0
|
0
|
0
|
|||||||
Olive Leaf Extract (6)
#
|
0
|
3A
|
0
|
0
|
3A
|
0
|
3A
|
2B
|
3A
|
0
|
0
|
|||||||
Cats Claw |
0
|
3B
|
3A
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|||||||
Pycnogenol
|
0
|
3B
|
0
|
3B
|
0
|
3A
|
0
|
2A
|
0
|
0
|
0
|
|||||||
Epitalon
|
0
|
3A
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
3A
|
|||||||
Lithium (5)
%
|
3A
|
3B
|
3A
|
0
|
0
|
3A
|
3A
|
3A
|
0
|
0
|
3A
|
|||||||
Zinc #
|
0
|
2
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
3
|
|||||||
Legend Powerfull Combinations: (1) ALCAR, Alpha Lipoic Acid, Coenzyme Q10 - Reduces Lipofucin, Maintains Mitochondria Function, Protects Telomeres (2) L-Carnosine, Blueberry Extract - Increase stem cell proliferation by 80% (3) L-Carnosine, Benfotiamine and ALCAR synergistically to inhibit AGEs. (4) Curcumin and Vitamin D3 remove beta-amyloids from the brain. (5) Increased Autophagy per GV's "Autophagy – the housekeeper in every cell that fights aging." (6) Reduced epigenetic signaling to cancel cancer as seen in GV's "Slaying Two Dragons with One Stone". Notes: + Needs source citations ! If taking high dosages of L-Carnosine (over 1500 mg) - Taurine supplementation is recommended to prevent depletion in the kidneys. Taurine is also necessary for healthy enzime interactions at the cellular level. Histidine supplementation is recommended to prevent histimine depletion which is important to a healthy immune system. Higher levels of Histidine in the system can reduce inflammation. In addition to their anti-AGE action, Carnosine and Histidine protect against alcohol-induced liver damage and depression. ^ Unfortunately, the specific types of AGEs affected by alagebrium, also known as ALT-711, are more important in rats than humans. The promising results in animals were never replicated in human studies. # Supplements on Vincent E. Giuliano's regimen list in the Anti-Aging Firewalls blog. % Prolonged high dosages may cause cancer, however prolonged low dosages have proven to extend human lifespans. |
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